NASH is expected to become the leading cause for liver transplants in the United States. MET642 was generally well-tolerated, with no serious adverse events reported. We believe our product candidates may be used as therapies to treat diseases beyond NASH. We are aware of both private and public companies with development programs in NASH. A single Phase 3 trial may be sufficient in certain circumstances. The cost of preparing and submitting an NDA is substantial. The FDA does not regulate the behavior of physicians in their choice of treatments. The term remuneration has been interpreted broadly to include anything of value. Coverage policies and third-party reimbursement rates may change at any time. The requirements may differ across the EU Member States. Investing in our common stock is speculative and involves a high degree of risk. We were incorporated in 2014 and commenced operations in 2015. As of December 31, 2020, we had an accumulated deficit of $120.7 million. Adequate additional financing may not be available to us on acceptable terms, or at all. In addition, our clinical trials may be affected by the COVID-19 pandemic. We will face significant competition in seeking appropriate collaborators. Collaborations are complex and time consuming to negotiate and document. The degree of future protection for our proprietary rights is uncertain. In this case, we could ultimately be forced to cease use of such trademarks. We may not be able to protect our intellectual property rights throughout the world. Similar requirements exist in Europe. Insurance coverage is increasingly expensive. 62 & We may also be subject to more stringent state law requirements. These shares will become available to be sold on March 16, 2021. Therefore, these provisions could adversely affect the price of our common stock. However, we have not opted out of this provision.