They are the only receptors that can "integrate" extracellular and intracellular stimuli. Structural specializations of α4β7 an integrin that mediates rolling adhesion. Data are mean ± SD of 26 donors. Efficacy has been established in a number of syngeneic murine tumor models. We and AbbVie have each agreed to certain exclusivity obligations under the agreement. In connection with the exercise of the option, AbbVie paid us $20.0 million. Thus, we may not be able to meaningfully protect our trade secrets. The first reports were due in 2014 and must be submitted on an annual basis. Amounts allocated to federal grants and contracts may be reduced or eliminated. It is unknown how long these disruptions could continue, were they to occur. As of December 31, 2020, we had approximately 89 full-time employees. We may not obtain foreign regulatory approvals on a timely basis, if at all. We are subject to income and non-income taxes in the United States. Competition from many sources exists or may arise in the future. Some of our product candidates may be studied in combination with third-party drugs. Our existing discovery collaboration with Schrödinger is important to our business. In addition, there is a natural transition period when a new CRO begins work. Litigation may be necessary to defend against these claims.
