Product description
| CUSIP | Symbol | Name | Title Of Class | Value in 1000's | Amount | |
|---|---|---|---|---|---|---|
| 12674W109 | 12674W109 | Cabaletta Bio, Inc. | COM | 702 | 662063 | |
| 901384107 | 901384107 | 2seventy bio, Inc. | COMMON STOCK | 27228 | 2062744 | |
| 004225108 | 004225108 | ACADIA Pharmaceuticals Inc. | COM | 590702 | 41923486 | |
| 00288U106 | 00288U106 | AbCellera Biologics Inc. | COM | 111294 | 10450180 | |
| 00449L102 | 00449L102 | Achilles Therapeutics plc | SPONSORED ADS | 6530 | 2591366 | |
| 00653A107 | 00653A107 | Adaptimmune Therapeutics plc | SPONSORED ADR | 16712 | 9830877 | |
| 00773J103 | 00773J103 | Aeglea BioTherapeutics, Inc. | COM | 1722 | 3410106 | |
| 008064107 | 008064107 | Aerovate Therapeutics, Inc. | COM | 32354 | 2070010 | |
| N01045108 | N01045108 | Affimed N.V. | COM | 18273 | 6596830 | |
| 00973Y108 | 00973Y108 | Akero Therapeutics, Inc. | COM | 1119 | 118378 | |
| 014442107 | 014442107 | Alector, Inc. | COM | 2431 | 239228 | |
| 01626L105 | 01626L105 | Aligos Therapeutics, Inc. | COM | 2512 | 2076400 | |
| G01767105 | G01767105 | Alkermes plc | SHS | 44685 | 1500000 | |
| 01671P100 | 01671P100 | Allakos Inc. | COM | 2201 | 703050 | |
| 02155H200 | 02155H200 | Altimmune, Inc. | COM | 24282 | 2075403 | |
| 023111206 | 023111206 | Amarin Corporation plc | SPONSORED ADR | 31543 | 21169805 | |
| 032724106 | 032724106 | AnaptysBio, Inc. | COM | 8672 | 427179 | |
| 04351P101 | 04351P101 | Ascendis Pharma A/S | SPONSORED ADR | 451103 | 4852655 | |
| 046513107 | 046513107 | Atara Biotherapeutics, Inc. | COM | 5797 | 744186 | |
| 04746L104 | 04746L104 | Athira Pharma, Inc. | COM | 3175 | 1040834 | |
| 04965G109 | 04965G109 | Atreca, Inc. | CL A COM | 6324 | 3532760 | |
| 07725L102 | 07725L102 | BeiGene, Ltd. | SPONSORED ADR | 1888611 | 11668897 | |
| 079481404 | 079481404 | Bellicum Pharmaceuticals, Inc. | COM | 296 | 249123 | |
| 09077B104 | 09077B104 | BioAtla, Inc. | COM | 2351 | 825000 | |
| 09058V103 | 09058V103 | BioCryst Pharmaceuticals, Inc. | COM | 134480 | 12710818 | |
| 09061G101 | 09061G101 | BioMarin Pharmaceutical Inc. | COM | 631510 | 7620494 | |
| 09077A106 | 09077A106 | Biomea Fusion, Inc. | COM | 25213 | 2104559 | |
| 12233L107 | 12233L107 | Burning Rock Biotech Limited | SPONSORED ADS | 609 | 209131 | |
| 152309100 | 152309100 | Centessa Pharmaceuticals plc | SPONSORED ADS | 5490 | 1127273 | |
| 157085101 | 157085101 | Cerus Corporation | COM | 84997 | 16067558 | |
| 16383L106 | 16383L106 | ChemoCentryx, Inc. | COM | 44422 | 1792657 | |
| 16961L106 | 16961L106 | Chinook Therapeutics, Inc. | COM | 44321 | 2534102 | |
| 22663K107 | 22663K107 | Crinetics Pharmaceuticals, Inc. | COM | 15433 | 827480 | |
| 23257D103 | 23257D103 | CymaBay Therapeutics, Inc. | COM | 6403 | 2170464 | |
| 23284P103 | 23284P103 | Cyteir Therapeutics, Inc. | COM | 7904 | 2643640 | |
| 23306J101 | 23306J101 | DBV Technologies S.A. | SPONSORED ADR | 37266 | 14614264 | |
| 23345J104 | 23345J104 | DICE Therapeutics, Inc. | COM | 9129 | 588235 | |
| 24823R105 | 24823R105 | Denali Therapeutics Inc. | COM | 17327 | 588738 | |
| 25056L103 | 25056L103 | Design Therapeutics, Inc. | COM | 20113 | 1436636 | |
| 28036F105 | 28036F105 | Edgewise Therapeutics, Inc. | COM | 3980 | 500000 | |
| 29384C108 | 29384C108 | Entrada Therapeutics, Inc. | COM | 59266 | 4865819 | |
| 29428V104 | 29428V104 | Epizyme, Inc. | COM | 1470 | 1000000 | |
| 30048L203 | 30048L203 | Evofem Biosciences, Inc. | COM | 2919 | 2583616 | |
| 31572Q808 | 31572Q808 | FibroGen, Inc. | COM | 8614 | 815718 | |
| 344174107 | 344174107 | Foghorn Therapeutics Inc. | COM | 612 | 45027 | |
| 34633R104 | 34633R104 | Forma Therapeutics Holdings, Inc. | SHS | 13951 | 2024876 | |
| 359664109 | 359664109 | Fulgent Genetics, Inc. | COM | 10985 | 201444 | |
| 37186H100 | 37186H100 | Genetron Holdings Limited | ADS | 774 | 455306 | |
| 37890U108 | 37890U108 | Global Blood Therapeutics, Inc. | COM | 119253 | 3732502 | |
| 43906K100 | 43906K100 | HOOKIPA Pharma Inc. | COM | 3913 | 2400481 | |
| 413197104 | 413197104 | Harmony Biosciences Holdings, Inc. | COM | 6028 | 123600 | |
| 427746102 | 427746102 | Heron Therapeutics, Inc. | COM | 22687 | 8131678 | |
| G46188101 | G46188101 | Horizon Therapeutics Public Ltd Co | SHS | 91605 | 1148504 | |
| 449585108 | 449585108 | IGM Biosciences, Inc. | COM | 56905 | 3156102 | |
| N44445109 | N44445109 | Immatics N.V. | SHS | 38531 | 4423731 | |
| 45258D105 | 45258D105 | Immunocore Holdings plc | ADS | 94048 | 2520730 | |
| 45337C102 | 45337C102 | Incyte Corporation | COM | 2746628 | 36154117 | |
| 45790W108 | 45790W108 | Inozyme Pharma, Inc. | COM | 510 | 106999 | |
| 457669307 | 457669307 | Insmed Incorporated | COM PAR $.01 | 42516 | 2156001 | |
| 457669AB5 | 457669AB5 | Insmed Incorporated | Note 0.75% 6/1/2028 | 33278 | 40000000 | |
| 45783C101 | 45783C101 | Instil Bio, Inc. | COM | 17989 | 3893700 | |
| 46185L103 | 46185L103 | Invitae Corporation | COM | 24091 | 9873488 | |
| 46185LAB9 | 46185LAB9 | Invitae Corporation | Note 2.0% 9/1/2024 | 8087 | 10300000 | |
| 48576A100 | 48576A100 | Karuna Therapeutics, Inc. | COM | 8851 | 69966 | |
| 49372L100 | 49372L100 | Kezar Life Sciences, Inc. | COM | 512 | 61946 | |
| G5269C101 | G5269C101 | Kiniksa Pharmaceuticals, Ltd. | COM CL A | 27128 | 2799577 | |
| 50015M109 | 50015M109 | Kodiak Sciences Inc. | COM | 132252 | 17310490 | |
| 501147102 | 501147102 | Krystal Biotech, Inc. | COM | 53036 | 807735 | |
| 501575104 | 501575104 | Kymera Therapeutics, Inc. | COM | 56704 | 2879825 | |
| 52187K101 | 52187K101 | Leap Therapeutics, Inc. | COM | 644 | 559705 | |
| 52490G102 | 52490G102 | Legend Biotech Corporation | SPONSORED ADS | 47116 | 856658 | |
| 54142F102 | 54142F102 | LogicBio Therapeutics, Inc. | COM | 158 | 451478 | |
| 556099109 | 556099109 | MacroGenics, Inc. | COM | 2633 | 892579 | |
| 558868105 | 558868105 | Madrigal Pharmaceuticals, Inc. | COM | 107314 | 1499213 | |
| N5749R100 | N5749R100 | Merus N.V. | COM | 22536 | 995397 | |
| 60468T105 | 60468T105 | Mirati Therapeutics, Inc. | COM | 94639 | 1409784 | |
| 62921N105 | 62921N105 | NGM Biopharmaceuticals, Inc. | COM | 709 | 55294 | |
| 632307104 | 632307104 | Natera, Inc. | COM | 3544 | 100000 | |
| 64049K104 | 64049K104 | Neoleukin Therapeutics, Inc. | COM | 3936 | 3821740 | |
| 65344D109 | 65344D109 | NexImmune, Inc. | COM | 32 | 20000 | |
| 65487U108 | 65487U108 | Nkarta, Inc. | COM | 4928 | 400000 | |
| 67080M103 | 67080M103 | Nurix Therapeutics, Inc. | COM | 49187 | 3882125 | |
| 68386J208 | 68386J208 | Opthea Limited | SPONSORED ADS | 16986 | 2696191 | |
| 68906L105 | 68906L105 | Otonomy, Inc. | COM | 17498 | 8412634 | |
| 69404D108 | 69404D108 | Pacific Biosciences of California, Inc. | COM | 24067 | 5444963 | |
| 702712100 | 702712100 | Passage Bio, Inc. | COM | 276 | 117161 | |
| 74065P101 | 74065P101 | Prelude Therapeutics Inc. | COM | 52846 | 10123824 | |
| 74365U107 | 74365U107 | Protara Therapeutics, Inc. | COM STK | 585 | 199671 | |
| 75615P103 | 75615P103 | Reata Pharmaceuticals, Inc. | CL A | 6807 | 223976 | |
| 75955J402 | 75955J402 | Relmada Therapeutics, Inc. | COM | 9402 | 495113 | |
| 76029N106 | 76029N106 | Replimune Group, Inc. | COM | 62772 | 3591081 | |
| 76155X100 | 76155X100 | Revolution Medicines, Inc. | COM | 4331 | 222222 | |
| 76243J105 | 76243J105 | Rhythm Pharmaceuticals, Inc. | COM | 17119 | 4125062 | |
| 803607AB6 | 803607AB6 | Sarepta Therapeutics, Inc. | DBCV 1.5% 11/15/2024 | 36577 | 29174000 | |
| 81181C104 | 81181C104 | Seagen Inc. | COM | 8300656 | 46912266 | |
| 81749D107 | 81749D107 | Sera Prognostics, Inc. | CLASS A COM | 331 | 201562 | |
| 86889P109 | 86889P109 | Surrozen, Inc. | COM | 7500 | 2500000 | |
| 86889P117 | 86889P117 | Surrozen, Inc. | W EXP 8/11/2026 | 159 | 833333 | |
| 87164F105 | 87164F105 | Syndax Pharmaceuticals, Inc. | COM | 2130 | 110729 | |
| 87808K106 | 87808K106 | TCR2 Therapeutics Inc. | COM | 2184 | 753064 | |
| 89854M101 | 89854M101 | TScan Therapeutics, Inc. | COM | 8758 | 2784792 | |
| 87424L108 | 87424L108 | Talis Biomedical Corporation | COM | 6191 | 7624835 | |
| 87583X109 | 87583X109 | Tango Therapeutics, Inc. | COM | 3398 | 750000 | |
| 89422G107 | 89422G107 | Travere Therapeutics, Inc. | COM | 79959 | 3300009 | |
| 89610F101 | 89610F101 | Tricida, Inc. | COM | 14550 | 1503090 | |
| 90400D108 | 90400D108 | Ultragenyx Pharmaceutical Inc. | COM | 28098 | 470974 | |
| 92337R101 | 92337R101 | Vera Therapeutics, Inc. | CL A | 4537 | 333333 | |
| 92337C104 | 92337C104 | Verastem, Inc. | COM | 31307 | 26988898 | |
| 92539P101 | 92539P101 | Verve Therapeutics, Inc. | COM | 21645 | 1416530 | |
| 92731L106 | 92731L106 | Vincerx Pharma, Inc. | COM | 319 | 241379 | |
| 929033108 | 929033108 | Vor Biopharma Inc. | COM | 5660 | 1138768 | |
| 98420N105 | 98420N105 | Xenon Pharmaceuticals Inc. | COM | 22865 | 751639 | |
| 98985W102 | 98985W102 | Zymeworks Inc. | COM | 9055 | 1708472 | |
| 002120202 | 002120202 | aTyr Pharma, Inc. | COM | 1060 | 374395 | |
| 04016X101 | 04016X101 | argenx SE | SPONSORED ADR | 424178 | 1119557 | |
| 09609G100 | 09609G100 | bluebird bio, Inc. | COM | 10349 | 2499715 | |
| 46565G104 | 46565G104 | iTeos Therapeutics, Inc. | COM | 3097 | 150346 |