Nerves can be damaged in several ways. Given the right conditions, peripheral nerves have the ability to regenerate. 2000 Oct;106(5):1036-45; discussion 1046-8 and Wangensteen KJ, Kalliainen LK. doi: 10.1007/s11552-009-9245-0. Avance Nerve Graft does not require immunosuppression for use. The Distribution Agreement terminates on June 30, 2027. We expect the number of direct sales professionals to increase over time. In the February 2020 edition of the journal Microsurgery, Safa, et al. published updated results from the RANGER registry. The publication included 385 subjects with 624 nerve repairs. No related adverse events were reported. The study included 113 Avance Nerve Graft repairs and 49 conduit repairs. The need for the surgical repair of damaged or transected nerves is a global opportunity. Axogen also distributes Axotouch Two-Point Discriminator. The study completed initial subject enrollment in July 2020. Such audit resulted in one Form 483 observation on tissue tracking. The FDA has broad regulatory compliance and enforcement powers. RANGER is designed to allow up to 2500 subjects. Outcomes analysis demonstrated meaningful levels of sensory recovery. The study results were published by Means, et al. These requirements are dynamic in nature and, as such, are continually changing. New regulations may be promulgated at any time and with limited notice. Axogen's operations are registered with FDA CBER, as a tissue establishment. Zaderej joined Axogen Corporation in May 2006. Eric A. Sandberg, Chief Commercial Officer (Age 56)Mr. Martinez has served as Axogen's Chief Human Resources Officer since October 2018. Mr. Donovan has a BS in Chemical Engineering and an MBA from the University of Akron. Our expense levels are based, in part, on our expectations as to future revenue. We received approval to distribute Avance Nerve Graft in Germany in December 2019. Outside of the U.S., reimbursement systems vary significantly by country. "We are responsible for the regulatory compliance of the Axoguard Nerve Cap. Finally, regulations in both the U.S. and other countries are subject to constant change. See "Business — Government Regulations." Healthcare law and policy changes may have a material adverse effect on us. We depend on the maintenance of exclusive licenses. Our common stock is listed on The Nasdaq Capital Market under the symbol "AXGN." Payment requirements under the credit facility and RPA will increase our cash outflows.
